Tacrolimus for Lichen planus
About 1 month ago I encountered a script for tacrolimus ointment use in the mouth mucosal. Tacrolimus is an immunosuppressive drug usually used for atopic dermatitis.
Upon calling the doctor, I found out that it is an off-label use of the medication for a condition known as Lichen Planus in the mouth.
An overview from Epocrates:
Lichen planus is a chronic inflammatory disease of the skin and/or mouth. Lesions often may be described by the "5 Ps" - pruritic, planar, purple, polygonal, papular. Onset is most common in middle-aged adults between the ages of 30 and 60 years but in rare circumstances children are affected. Though the exact cause is unknown, allergic or immune reactions are likely related.
Risk factors include exposure to medications, dyes, or other chemical substances, as well as alterations in cytokine expression related to hepatitis C. Topical and/or systemic corticosteroids, retinoids, calcineurin inhibitors, immunosuppressants, and phototherapy may be required to achieve disease control.
Read more here.
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Upon calling the doctor, I found out that it is an off-label use of the medication for a condition known as Lichen Planus in the mouth.
An overview from Epocrates:
Lichen planus is a chronic inflammatory disease of the skin and/or mouth. Lesions often may be described by the "5 Ps" - pruritic, planar, purple, polygonal, papular. Onset is most common in middle-aged adults between the ages of 30 and 60 years but in rare circumstances children are affected. Though the exact cause is unknown, allergic or immune reactions are likely related.
Risk factors include exposure to medications, dyes, or other chemical substances, as well as alterations in cytokine expression related to hepatitis C. Topical and/or systemic corticosteroids, retinoids, calcineurin inhibitors, immunosuppressants, and phototherapy may be required to achieve disease control.
Read more here.
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